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Scientists Identify Possible Key to Drug Resistance in Crohn's Disease

Now scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a normally small subset of immune cells that may play a major role in the development of Crohn's disease generally and in disease-associated steroid resistance specifically.
今は、Scripps Research Institute(TSRI)のFloridaキャンパスからの科学者は、特に一般に、そして、疾患関連のステロイド抵抗でクローン病の発生で主な役割を果たす可能性がある免疫細胞の正常に小さいサブセットを特定した。

Within healthy individuals, only approximately 5 to 10 percent of CD4+ T cells are MDR1-expressing TH17 cells.
健常な個人の範囲内で、CD4+ T細胞のわずか約5~10パーセントは、MDR1を表しているTH17細胞である。

In contrast, the study found that of the CD4+ T cells found in actively inflamed tissue taken from Crohn's patients, nearly 60 percent were MDR1+ TH17 cells.
対照的に、本研究で、Crohnの患者からとられる能動的に炎症を起こした組織で見つかるCD4+ T細胞のうち、ほぼ60パーセントがMDR1+ TH17細胞であったことが明らかになった。

The study also showed that these cells are resistant to both natural and synthetic steroids, a class of drugs considered a first-line defense against most autoimmune diseases.

"If a T cell expresses MDR1, it is likely to have an unfair growth advantage over surrounding T cells," Sundrud said.

"When exposed to steroids, it's this subset of cells that will survive and thrive."

by travelair4000ext | 2014-01-11 15:48 | 翻訳  

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